发信人: mail@Lion (传统医学快递), 信区: TradMedicament
标  题: Re: [转信]◆ 长生不死(帝释天?)(agency)
发信站: 狮子吼站 (Thu Jun 20 16:29:52 1996)
转信站: Lion

v发信人: mefistofele@Maple (英国绅士), 信区: TraditionalMed
标  题: Re: [转信]◆ 长生不死(帝释天?)(agency)
发信站: 台大医学院◎枫城杏话◎ (Mon Jun 17 08:51:43 1996)
转信站: Maple (local)

: To reverse aging, Fossel proposes three methods: (1) open delivery of
: telomerase<终止分裂□?><注> or a telomerase-like compound to cells,
: <提供终止分裂□?给细胞> (2) adding a sequence coding for telomerase to DNA
: by a vector<利用载体vector将终止分裂□密码序列加入DNA中><仅适用於胚胎尚未分
: 化细胞>, and (3)unrepressing the endogeneous<生自内部的> telomerase sequence
: that is not expressed in somatic(身体的) cells but is expressed in germ(幼芽
: ) cells<将成体内不作用的终止分裂□基因序列解压制, 使如在幼体时一样表现>.
: Fossel thinks that (3) is most likely to be successful (see also the posting
: G.J. Griffits in March discussing these three methods).
: Finally, Fossel optimistically (?) forecasts that first trials on animals

                  乐观地预测

: will be conducted by the end of the decade, firs clinical trials by 2005
: and, by 2015, telomarase therapy should be available to most citizens in the
: wealthier part of the world (i.e., G-7 countries).
: vHere are a few questions that the book inspired.
: 1. Should we take this book seriously?  Are Fossel's predictions for
: the timetable of the aging research at all realistic? I hope that more
: knowledgeable readers of this newsgroup and researchers in the field,
: in particular, also respond to this question (if you haven't read the book,
: simply address the plausibility<似合理的解释> of the telomerase theory).
: 2. If cell division is used to replace worn-down cells with cells that are
: capable of maintaining homeostasis<原状稳定>, fight free radicals<抗自由基>
: etc., what about cells that don't divide, such as neurons and some muscle
: cells (if I remember correctly)?  Shouldn't neurons wear down eventually and
: thus impose a limit to lifespan<寿命>, even if we can sustain the
: immortality of other cells by a telomarase inducer<诱因>?  (I hope this is a
: sensible question, though I have a feeling that I'm missing a simple point
: somewhere).
: 3. Is it plausible<似合理的> that we will be able to engineer a narrow
: 'corridor'<走廊> in which we can induce enough telomarase to stop, or even
: reverse, aging, but not enough to cause cancer<癌细胞为不死不分化且不断分裂
: 的永生细胞> in cell?  What is the 'limiting condition' for such a corridor?
:  The discussion between Jean-Pierra Issa of Johns Hopkins and Mike West of
: Geron has been very useful, but I would love to see some third opinionsv
: and/or a reiteration<重述> of the argument.
: 4.  For a college student (or anybody for that matter) who hopes to go
: on and make a contribution in this fascinating field with massive social
: implications, what type of graduate education would you recommend and why?
:  Obviously, this is related to the question which theory of aging is the
: correct one, but I would appreciate any mentorship<辅导> or advice.

这们学问在学 biology 的人叫做 cell cycle

: 注<telomere ; telomerase: telo终mere裂殖粒 -ase□ 姑且译为终止分裂素;终止分
: 裂□ 尚期指正>

about correct

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